26 Apr

Modafinil Seizures by US Customs Increase

Exam season is just around the corner and more students are turning to modafinil to stay sharp and prepare for the rigorous tests that lie ahead. The trend continues to grow despite opposition from the United States Customs department.

Seizures of Ritalin, Adderall, and even modafinil have more than doubled over the last five years. It’s been proven to work as students find themselves able to concentrate better and learn more just in time for exams which may determine whether they pass or fail an academic semester. And more of these medicines are being ordered through online pharmacies without a prescription.

The United States has a very strict no-imports policy when it comes to prescription medicines. While the people who buy them are almost never charged with a crime unless they are caught importing massive quantities with intent to resell, the law is still firmly in place. The most common reason politicians give for these rules is to protect consumers from potentially dangerous consequences. Of course, severe side effects do occur in a small percentage of the population, and without a doctor to supervise, the chances of this occurring are greater.

However, modafinil has been proven to be safe for everyone and even the most serious side effects are not life threatening. Customs officials, in response, bring up another issue: Faulty products with the potential to kill. Yet even though the counterfeit and subpar quality drug industry pulls in over $70 billion dollars annually, few if any deaths occur in modern countries. It makes sense: Why would a counterfeit drug maker want to kill their customers? The truth is that they often put very little of the active ingredient and rely on the placebo effect. You take a pill that in reality does almost nothing to you, but you think you’re getting something real, and you sense some vague effect.

The real reason customs enforces this law so strictly is that it protects the US pharmaceutical industry, the largest in the world. Modafinil imported from India is made by reputable companies with great safety records. Modafinil itself has not been found to cause death or serious side effects. But the brand-name Provigil costs over $40 a pill in the United States, and to keep the profits coming in the US needs to make sure that individuals don’t import pills from abroad.

So know that while you may be placing an order from a trustworthy vendor, your order may not make it into the United States, especially as they are on high alert during exam season. Having said that, it’s impossible for them to filter every shipment that comes into the country as the USPS reports around 500 million packages delivered every day. While much of that is domestic, it means that inspecting every shipment is unrealistic.

19 Apr

Websites with User Reviews for Modafinil

This blog is full of information about how modafinil works and how it can benefit you. But don’t just take our word for it. If you’re interested in reading more from actual people who have tried modafinil, we’ve compiled some helpful links to get you started.

Best User Reviews for Modafinil: Erowid

One of the oldest non-profit websites related to drugs and their effects, Erowid is an incredible source of information for people who are curious about trying just about anything. They have pages on common substances such as caffeine as well as research chemicals you’ve never heard of. Erowid is run by very dedicated people and filters out experience reports that are not well-written or that make sweeping generalizations. As a result, you get more objective and precise information. There is a page specifically for modafinil experiences, which are broken down in to good ones, bad ones, and everything in between. Erowid also doesn’t post experiences that repeat what another one already says, so if you see 5 good ones and 4 bad ones, you should not assume that this means the chances of a bad experience are around 50/50. Rather, it just means that Erowid is looking to represent all possible outcomes.

Drugs-Forum

Drugs-forum.com is a place where people can gather to talk about literally any drug that’s available, from certified pharmaceuticals to illegal substances. This site is a great source of honest information from users, but often lacks some of the technical details you might find on other websites. Keep in mind that the users here have usually tried many other drugs, so their responses may be wildly different. Reading about people trying modafinil with other substances is common. The biggest advantage is that the forum has over 230,000 members, meaning that you will likely be able to find a wide sample of users. Check out modafinil related posts here.

Drugs.com

This site is considered the most reputable source of reviews for prescription medications. User reviews must mention specifically which condition they took the medicine for, including off-label ones such as ADHD which have not been fully approved by the FDA yet. There are nearly 200 reviews for modafinil with an average score of 8.2 on their ten-point scale. One of the downsides of these kinds of reviews is of course the fact that many people may give the medicine a 1 or a 10 without carefully considering the results. Regardless this is a great resource if you have a specific condition and would like to find other people’s experiences with modafinil.

Reddit Afinil

Reddit has a section for just about everything, including some things you probably didn’t even know existed (and maybe didn’t want to). The –afinil sub contains plenty of threads about modafinil and armodafinil, many of which discuss purchasing and vendor-related experiences. However, they also include reviews of specific suppliers. This is exactly what you need if you’ve been thinking about buying modafinil but aren’t sure where to start. Likewise, you can find good user reviews and personal experiences from people of all walks of life.

Brainmeta

Brain Meta is one of my favorite sites because of its scientific nature. It focuses heavily on nootropics but does so in an intelligent way. Exactly what a nootropic forum should be. Conversations tend to be of a more intellectual and analytical nature, which can lead to some high-quality reviews. Unfortunately one of the downsides is that the site boasts fewer users and thus there are less experiences to sift through. When you do find a thread, you can expect it to contain several profound posts and in-depth discussion.

 

An educated decision is always a better decision. If you’re thinking about trying modafinil you should read up on these user reviews to get a better idea of how it may work for you.

18 Apr

Modafinil as a Treatment for PAH

Modafinil is well known now for how great it handles things like promoting wakefulness, treating narcolepsy, excessive daytime sleepiness from sleep apnea, shift work sleep disorder, helping immensely with focus, and even treating stimulant addiction. However, there are many “off-label” uses that have appeared, from treating neurological fatigue to a recent discovery that shows it could help with Pulmonary Arterial Hypertension, or PAH. New information published less than a month ago shows promising potential for patients with PAH.

PAH: Pulmonary Arterial Hypertension

If you’re wondering what PAH actually is, it’s a life–threatening condition that can get worse over time. It occurs when the very small arteries that go from your heart to your lungs become constricted or blocked making it harder for the blood to flow through them and raising your blood pressure. This condition causes the heart to pump harder to keep the blood flowing and will eventually weaken the heart muscles and can lead to heart failure. This condition can be caused for a number of reasons, including genetics, but is mostly due to various conditions that tend to cause high blood pressure (ex. Sleep apnea, emphysema, and more). You might not even notice some of the symptoms for a long time, though they include chest pain, fatigue, passing out, and swelling of the ankles and legs.

Can Modafinil Treat PAH?

It was recently found that modafinil can help improve PAH for those that are suffering from it due to the fact that it causes vasorelaxation (widening of the blood vessels) and helps to decrease medial thickening through down regulation of certain receptors, specifically the ET-1, ERA, and KCa3. In layman’s terms, it blocks the signals that tell an artery to get thicker. What’s unusual is that most stimulants do the exact opposite: Causing vasoconstriction and raising blood pressure. This meaningful study was conducted in Seoul, South Korea among various departments in the Ewha Womans University. Although this study was done on rats, the success is great news because human tests will follow very shortly and this could open up a whole new use for modafinil that is no longer just “off-label”.

The methods that were used in this study was done on six week old Sprague Dawley rats. The groups were split up into three with a control group that was given a saline solution, the modafinil group, and a group that was given monocrotaline (MCT). MCT actually creates PAH in rats, so this would make that group stand out more in the study. The modafinil group showed large signs of improvement as blood pressure dropped. The dosage of modafinil that was used was 50mg/kg, which would be a very large dose in a human. More research is needed to determine how much is necessary for human trials.

What’s next?

Modafinil keeps presenting new and exciting possibilities. Researchers love it because it has a proven track record of safety and has little to no potential for abuse or addiction. This is one of the most important aspects of a medication for patients with chronic conditions. Since they’ll likely be taking their pills often and potentially forever, it’s important to make sure that the medicine doesn’t do more harm than good in the long term. Modafinil fits the bill. It is very likely that in the future there will be more studies finding more uses for modafinil.

Keep in mind that human trials are still a ways off, and you should consult a medical professional if you have a condition like PAH before using modafinil. Although it is one of the safest drugs on the market it is always necessary to get a professional opinion.

08 Apr

The Future of Modafinil

Will Modafinil be replaced any time soon?

The pharmaceutical world is constantly changing. Companies and researchers discover new things about old drugs while constantly searching for the next big hit. Modafinil is no exception to this. It was not the original –afinil, but it has been one of the longest lasting and is becoming the most widely used. So what is next for modfinil and who will take its place?

Not digital, Analog

As you probably know modafinil is one of the most common and widely used drugs for focus and wakefulness because of its safety. However, there are already substances out on the market and in development that are analogs of modafinil and could end up replacing it. Analogs are similar drugs that produce nearly identical effects. Many labs create these analogs for drugs to get better or longer lasting effects, or to reduce harmful side effects. Armodafinil is one of the only similar drugs on the market that is known to produce similar effects and that has had research done. This can be found under the brand name Nuvigil. Since the two are so similar with very little differences you might not notice if someone switched your pill. Armodafinil is meant to provide you with the focus and wakefulness that you get with modafinil and to keep that safety, which studies have shown so far to be true.

Future Hits, or Future Failures?

There are other analogs, but it is uncertain whether they will produce the same effects, what their side effects are, or how safe they are for regular use. These are usually referred to as research chemicals because as the name implies they’re still in the R&D phase, although sometimes there is little to no research being done if pharmaceutical companies have little interest. Another term that is used that may be more common to some is ‘designer drug’. Two such substances in the –afinil family are bisfluoromodafinil and fluorafinil, though when searching for them you may only see them as CRL-40,940 and CRL-40,941. Since they aren’t being sold by any major company, they still carry scary laboratory names.

 Safety first

Very little is known about both bisluoromodafinil and fluorafinil at this time and the majority of information that is out there is just based on personal experiences that people have had with them. Often these research chemicals are produced in small, unregulated laboratories in China. Buying these designer drugs when they’re in their infancy is dangerous. Without proper studies, no one knows precisely how much to take, so they make an educated guess based off of their experiences with similar products. This is extremely risky: While two products may produce similar effects, their toxicity can be wildly different! For instance, both aspirin and acetaminophen reduce pain in similar ways. A person suffering from arthritis could take 3 grams of aspirin in a single day. If you took three grams of acetaminophen, you could die.

Making matters worse, you have no clue about any possible long term side effects. It could be many months or even years until there is reliable information about these two chemicals since modafinil is so effective at what it does there is really no incentive for labs to find a successor. Stick to what works, don’t take unnecessary risks when a perfectly proven product exists, and is readily affordable.

What’s next for Modafinil?

So then what is next for modafinil? Well, you can be certain that modafinil will be around for a long time, unless a pharmaceutical company invents a better version of it and can obtain a new patent, guaranteeing more profits. Even so, most analogs do not completely replace the previous drug. Modafinil has been very effective at not just the intended uses of things like focus, wakefulness, being alert, and helping out with problems like narcolepsy, but also has been shown to benefit stimulant addicts along with therapy. With no real risk of abuse or addiction it is one of the safest drugs of this kind on the market, especially when compared to commonly used things like Adderall or Ritalin with have been known to be abused and can be very addictive if used improperly. Modafinil is great at what it does and going to be around a long time doing it.

08 Apr

How to Use Armodafinil Properly

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How to Use Armodafinil, and Use it the Right Way!

There are many different types of products on the market today. Many of which involve medicines that affect how the body works. Each type of medication, over the counter or prescribed, work on different parts of the body for a variety of purposes. Some of the most recently known that is increasing in popularity in many circles today are the drugs that called nootropics. Nootropics are the group of medicines that’s being marketed as smart drugs, and this where Armodafinil comes in.

With each smart drug, it is important to note that they have different benefits, dosages, usages (short term and long term), and side effects. So, it is essential for people to they research well in advance. Especially, so that they will know what the different t affects will be prior to consuming them on a regular basis. To that end, here are some of the essential facts that you should know.

benefits

Currently, this product is being marketed as a smart drug that affects the way the brain functions. So, here’s some of the main benefits listed below;

This smart drug can be used by individuals who need help with increasing their alertness and their wakefulness. Essentially, some people may want to take this type of drug to increase their overall mental performance. It is now being sold as a prescription drug under the names Nuvigil and Waklert. and has been approved by the FDA.

Boosts energy and memory

Clears up brain fog so people can be more motivated.

Made for those who are suffering with excessive fatigue and daytime alertness

Treats sleep apnea, narcolepsy, and insomnia

People with sleep pattern irregular can also benefit from this kind of drug, specifically those that work off shifts

dosage

Armodafinil is considered to be one of the newest and most improved versions of this type of drug. To improve its make up, its made of a purer and refined version that’s known to be very effective. Presently, this smart drug is sold under the brand name of Nuvigil, which is available in tablets form in varying strengths. (i.e. 50, 150 or 250 mg). The dosage will also vary based on the condition. For instance, the dosage recommendation for people with narcolepsy is 150 – 250 mg daily.

long-term use and short-term use side effects

It is important to note that there are both short term and long term side effects so people should be aware of the list so that they know what they can expect. For instance, this smart drug may cause an individual to have headaches, dry mouth, nausea, difficulty sleeping , anxiety, and dizziness. If any of these problems do occur, it is important for the person to make sure that they contact their doctor. These side effects can range from mild to severe based on the individual and short term and long term usages.

comparison to other nootropics

Compared to other nootropics, this smart drug is considered to be much more effective. How to Use Modafinil ProperlyThis is because it is being released in its purest form as of recent. It is also considered to be one of the most powerful smart drugs on the market and has an FDA approval.

what will I feel when taking this

While the affects of this drug will vary from person to person, people may expect to feel more alert, sharp in focus instead of having a brain fog and the mood of the person will be improve as well. In some cases, people may find that they will have a reduction in appetite because it can also simulate the effects of an appetite suppressant.

research

There are numerous research studies that have been done over the years. One of the most notable is the affect that it has on adults who have ADHD. Based on these studies, it is very effective for those who have built up a high level of tolerance for other drugs.

legal status

This drug is different from other smart drugs since it has a legal status that has been approved by the FDA so it can be prescribed by a physician.

conclusion

As with any new or old drug, it is essential for people to review the ingredients and the side effects. For those who are considering it, is essential that they are familiar with the research and the case studies that have been done before consuming it. So, it is important that they are familiar with the long and short term side effects like dry mouth, dizziness, anxiety, difficult sleeping and other medical problems that they can experience.

04 Apr

Modafinil in the News

Modafinil in the News is a segment where we bring some of the latest developments in the modafinil world together here on Modafinil.co.uk

Modafinil, Schizophrenia, and Shenanigans

A study from 2008 in India reported that modafinil was a useful aid to patients taking atypical schizophrenia medications, specifically Olanzapine, Risperidone, and Clozapine. These medications are more affordable in underdeveloped countries and therefore are more commonly used to treat the prevalent mental disorder. Unfortunately they come along with two problematic side effects: Weight gain and daytime drowsiness. The researchers immediately thought of modafinil and put it to use.

And then they did so again in 2014, and once more in 2015. Or did they? Discover Magazine noted that the text between the 2015 and 2008 versions was 88% identical, and that one of the original authors works on the editorial board of the journal where the studies were published.

So, while the first test may have shown that modafinil helped these patients, it seems that any further tests could be nothing more than a fabrication. Hopefully some law-abiding westerners can take this brilliant idea and make it legit.

Smarter, safer, so says Scientific American

Safe, says the study

Scientific American has reported on a University of Oxford study which examined over 24 modafinil related investigations. What for? The Oxford researchers were looking to find solid evidence that modafinil helps with cognition. It’s been a hotly debated subject because every test has used a variety of different methods and that creates inconsistency. How do you test cognition, or brain power, anyway?

Well, the results came in loud and clear: The more complex the task in the study, the better the modafinil patients did compared to placebos. The simple tests showed no discernable improvement with modafinil, meaning that any difference they saw was still within the margin of error on the study.  Best part, they found no negative mental side effects from using the pills in any study, so they’re safe.

So what’s that mean for you? Get out there and put your pills to good use. Don’t waste them on the simple stuff, find something challenging that’ll really get the gears turning in that head of yours.

A New Formula for Narcolepsy

As patents expire, companies seek to find new ways to get their brand-name power back. One of those is by crafting up a new formula. The same modafinil when combined with another medicine in the same pill becomes an entirely new drug in the eyes of the patent office, and that means big profits for the pharmaceutical company. Theranexus is a new company pushing a new blend of their own medicine with modafinil to be even more effective for fighting narcolepsy.

Interestingly they’re backed by some pretty big people. CEA, one of the most important research institutes in France, is backing their project and pushing it forward.

When it comes to good modafinil research (and not that Indian funny business) the more the merrier, I say.

 

29 Mar

Can Modafinil Lower your Blood Pressure?

A new study from South Korea opens up the possibility that modafinil could be used to reduce high blood pressure. At the moment the study has only been performed on rats, but this would be an incredible find if it proceeded to human trials. Most stimulants increase blood pressure which makes them unsuitable for people with high blood pressure.

Modafinil might be able to drop those numbers

The dangers of hypertension are well known and documented, you can suffer heart attacks or aneurysms as well as long term organ damage. For someone with chronic hypertension, as opposed to a temporary spike in blood pressure like the kind you get when you’re angry in traffic, it’s important to keep a strict diet and be careful with strenuous activity. Caffeine is often ruled out as well.

Imagine not being able to do the same amount of work as you would like simply because it might make your heart explode. And furthermore, you need to avoid all the common things everybody else takes to stay awake. What if modafinil could be the solution for those people?

What about humans?

An older study from 1999 looked at the blood pressure in humans who were already taking modafinil. They found that their regular resting pressure didn’t decrease considerably. However, when they were under strain, such as jogging or lifting objects, their blood pressure didn’t increase as much as it normally did. This could prove to be essential to preventing sudden rises in pressure that are responsible for many of the fatal outcomes.

Did you know that mental stress can cause your blood pressure to rise? Think back to the days where you had to take a particularly painful exam, how you wracked your brain looking for the right answer. You could feel your head pounding. That’s a perfect example of how this works. The same 1999 study tested patients with mental exercises, like the types of questions commonly found on IQ tests. The results were positive: Modafinil limited the rise in blood pressure in those individuals.

At this point in time it’s unclear if modafinil will actually lower your blood pressure, but it may be able to prevent it from rising uncontrollably. That also means it’s safer for people who have high blood pressure. Regardless, if you have hypertension and are considering taking modafinil you should consult your physician prior to doing so, especially if you are already taking other medications to treat that condition.

It’s exciting to see the new developments in the modafinil arena, what new treatments will they find next?

18 Mar

Provigil Work-Shift Sleep Disorder

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 Provigil and Work-Shift Sleep Disorder

What is Provigil?

Provigil, also commonly known as Modafinil, is a drug that is designed to help treat sleep disorders such as narcolepsy, sleep apnea, and shift work sleep disorder. The drug works by altering neurotransmitters that are located within the human brain.

 

Benefits

Perhaps the biggest benefit of Provigil is that the drug helps those who take it stay more awake and active rather than feeling tired. This helps their minds stay much clearer as a result, essentially improving aspects such as concentration and even short-term memory.

 

Side Effects

As with virtually any other drug on the market, Provigil has its share of side effects, which include the following:

 

*Rapid weight loss

*Appetite suppression

*Headache

*Insomnia

*Hypertension

*Nervousness

*Dry mouth

*Nausea

*Vomiting

*Back pain

*Nausea

*Diarrhea

*Stuffy nose

*Upset stomach

*Anxiety

*Dizziness

 

Additionally, there is also the chance that this drug can cause skin reactions and other anxietymore serious side effects that can be severe enough to require medical treatment. If you begin to experience the following, stop taking the drug immediately and contact your doctor:

 

*Leg swelling

*Hives

*Blisters

*Skin peeling

*Difficulty swallowing

*Mouth sores

*Fever

*Shortness of breath

*Dark urine

*Jaundice

*Facial swelling

 

Dosages

The dosage amount for Provigil will depend on the particular sleep disorder that you are suffering from. For instance, if you suffer from narcolepsy, take no more than 200mg per day in the morning. If you suffer from sleep apnea, you will generally take the same amount at the same time of day. If you suffer from shift work sleep disorder, however, you will need to take no more than 200mg of Provigil per day no less than one hour before you begin your usual work shift. It is also worth noting that despite reports to the contrary, Provigil has note been approved by the Food and Drug Administration for pediatric attention deficit disorder.

 

Long-Term Use

Since the long-term effects of Provigil are not exactly known as of yet, the United States government has taken the step of classifying this drug as a Schedule IV controlled substance. This means that while the drug has a very low potential for abuse, it still requires a prescription from a licensed physician to obtain.

 

Short-Term Use

When Provigil is used on a short-term basis, not only can it help to, as previously mention, assist in the relief of various types of sleep disorders, but it can also help to improve cognition, increase concentration, and help with overall mental focus in individuals who take the drug.

 

Dangers

As previously stated, Provigil has been classified as a Schedule IV controlled substance by the United States government due to the fact that it has the potential to be abused. The Food and Drug Administration has issued warnings that there have been reports of this drug causing anxiety, hallucinations, and, in more serious cases, suicidal thoughts. Additionally, there is also the risk of skin infections that can occur, as one of the more serious side effects can be skin peeling.

 

Legal Status

The only way to obtain Provigil is through a prescription that is obtained through a licensed physician – no one else. This is because of the fact that the drug has been classified by the United States government as a Schedule IV controlled substance.

 

Use Among College Students

Since Provigil is designed to help combat various types of sleep disorders, it is seen as being one of the more popular go-to drugs for college students, especially those who are finding that they are having trouble sleeping due to all of the stress that they are experiencing from so much studying and stress that they go through thanks to college life. Then again, there are some college students who are somehow able to get their hands on a pill or two as a means to stay awake during the night and make it through those stressful all-night study sessions.

 

Conclusion

Provigil is certainly a drug that should, in no way, be obtained unless you have the legal means to do so. If you are a student who is just looking for a way to stay awake to try to get through an all-night study session for a big test the next day, make yourself a pot of coffee or buy a couple of energy drinks – don’t take this route, because chances are you will end up getting addicted to something that you will find it very difficult to get away from.

17 Mar

Using Modafinil to Lose Weight

One frequently reported side effect of modafinil is appetite suppression or in laymen’s terms, not feeling hungry. So is it possible to lose weight by using modafinil? The answer is a resounding “Yes”, but only if you do it right. There are some obstacles to making this work well.

The first issue is that you still need to eat. It might seem strange to talk about eating when the title is losing weight, but it’s extremely important. If your decreased appetite causes you not to eat at all, your metabolism will decline. In addition, this is incredibly unhealthy because you aren’t giving your body the nutrients it needs to run at top form. Modafinil might make you wakeful and alert, but it is no substitute for natural energy from food. The key to solving this problem is to eat small, light portions several times a day. This is what nutritionists already recommend, but people find it difficult to control their portions.  Modafinil will make that easy by curbing your appetite and allowing you to eat less.

In order to properly digest the food you do eat you’re going to have to stay well hydrated. Without water, the gastrointestinal system’s function declines, which can lead to constipation. I mention this because modafinil tends to excrete water from your body much faster than normal. You’ll probably find yourself visiting the restroom more often when you take modafinil. This is perfectly normal, but those fluids need to be replaced. Stay lubed up, keep the water flowing, and you should be able to process everything quite naturally.

So you’ve packed your lunch with small snacks to eat throughout the day, you’ve got a big bottle of water ready to go, you’re taking your pill every day, but you’re not losing weight. How come?

One of two things could be happening here and you need to be sure you’re being brutally honest with yourself. For one, are you eating the right types of foods throughout the day? A donut isn’t the right type of snack, for instance. If you’re packing heaps of calories into your mini-meals then you aren’t going to see any results at all. Modafinil doesn’t burn calories, it just makes you less likely to want to put things in your mouth.

Another potential obstacle is the “rebound effect”. Eventually modafinil wears off, likely after at least 12 hours. This can also inconveniently be right around the time you pull into your driveway and get home. If you haven’t eaten much during the day then when the pill’s effect subsides you might feel famished. That can cause you to “double down” so to speak and eat even more than you intended. So what can you do if this happens to you?

A good idea is to break up your dose into two smaller ones. If 200mg works for you, take 100mg first thing in the morning as you normally would. Then, after a few hours, take the rest. This will extend the duration of the effects later into the evening while keeping them light enough to allow you to fall asleep at a reasonable hour. If you take a large dose too late you’ll lie awake staring at your ceiling, and nobody wants that. But if you took 100mg at 10 AM, most of it will be out of your system by 10 PM, at which point you’d have less than 50mg in your body and would likely be able to rest well.

There truly is no such thing as a magic pill that’ll cause you to shed those extra pounds. Modafinil simply suppresses appetite, which means you still need to exercise some self-control when it comes to what you eat and when. Speaking of exercise, you should absolutely try to incorporate that into your routine. Modafinil will make you able to endure longer and harder activity, just ask the athletes who’ve been banned for taking it to get an advantage. If you put your reduced appetite together with a more active lifestyle, you can guarantee real meaningful weight loss.

14 Mar

Modafinil as a Cure for Addiction

When you think of modafinil you probably think about how it makes you focused or the energy it gives you, but what you probably don’t know is that modafinil can be used as a cure for addiction. Not what you’d expect, especially when that addiction is to stimulants like cocaine, but extensive research has shown this to be true.

Dr. Charles Dackis and some of his colleagues at the University of Pennsylvania Treatment Research Center reported having a second successful study. The study conducted included 62 individuals (44 men, 18 women) that had ingested $200 worth of cocaine, if not more, within the past 30 days. Dr. Dackis had his patients come to the clinic twice a week for individual cognitive-behavioral therapy sessions (CBT) and provide urine samples three times a week during the 8 week study. Each week the patients were given a week’s supply of modafinil and told to take four 100mg doses a day, while the other half of the group received similar looking placebo pills and told to do the same. It was found that 33% of the patients were able to abstain from cocaine use for three weeks or more. There have also been other studies conducted separately showing that this can work for addiction to other stimulants like methamphetamine.

Modafinil was not the only factor in helping those patients to overcome their addiction, but it did play a large role. Dr. Dackis claimed that modafinil’s modulation of glutamate, an abundant excitatory neurotransmitter, may account for the striking effect. He goes on to explain that some of the patients that used again claimed that the effects of modafinil seemed to have removed the typical urge to redose that they had always felt before. Others told him that they had simply flushed the cocaine down the toilet, something Dr. Dackis says he has never heard a patient say in his 25 years of treating addiction. Modafinil reverses the cocaine-induced neurochemical disruptions of glutamate and of dopamine-containing neurons in the brain’s reward centers. Those two neurotransmitters are responsible in part for the good feeling that you get from drugs. Clinically, modafinil’s effects are in many ways the opposite of the symptoms of cocaine withdrawal, which usually include oversleeping, depression, poor concentration, and craving. Modafinil is also not addictive, making it a good neutral tool for this study.

The same team went on to do another study including 210 patients this time with the plan to test the efficacy of two different doses. They divided the groups up with the same exact structure as the previous study having patients visit twice a week for cognitive-behavioral therapy sessions and providing three urine samples a week, however this time Dr. Dackis and his team would be using doses of 200mg, 400mg, and a placebo for some that would be taken daily. They did not find a notable difference between the different doses, though when they looked at the results by gender it was found that there was a slight improvement with 400mg among men.

It is amazing to think that modafinil can not only provide the average person with great focus, wakefulness, and overall improvement on cognitive function, but that it can also help someone suffering from addiction that needs that extra push to get clean. You shouldn’t try to recreate that study on yourself since it was not just modafinil that helped, but also the CBT sessions that were conducted by professionals. If you feel that is something that would benefit you then please do it under the supervision and guidance of your doctor.