03 Dec

What is Modafinil, and Why is It Used?

lucy

What is Modafinil, and Why is it Used?

Modafinil is a powerful wakefulness-promoting drug that is typically prescribed for Narcolepsy and ADHD, yet is also used off-label by healthy individuals looking for a boost, as it can sometimes pose a significant competitive advantage over the competition in high pressure jobs. Professions where the drug is commonly used is Banking, in University, and in the Start-Up community in Silicon Valley. Provigil can give you a significant boost in energy levels, mood, memory and focus, and often promotes significant vigilance and euphoria in the user.

Research on Modafinil

There have been loads of studies on Modafinil to prove its efficiency, even at .gov websites where clinical trials have been done proving its effectiveness. You can read more at these URL’s

https://medlineplus.gov/druginfo/meds/a602016.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286657/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/

https://www.ncbi.nlm.nih.gov/pubmed/22051208

What most of the data on Modafinil is currently showing is that it can enhance mood, memory and focus, and that it is actually clinically effective as a nootropic. You can read a more detailed article about its legitamacy right here: https://www.theguardian.com/science/2015/aug/20/narcolepsy-medication-modafinil-worlds-first-safe-smart-drug

This website review has Modafinil touted as the worlds first safe and effective Smart Drug, and for good reason, for the most part, Modafinil is non-addictive, and can easily be used What is Modafinil?long-term with few excess side effects. Modafinil user reviews often state that the drug gave a clean, mildly euphoric energy boost that helped to significanty maximize productivity.

Who Uses Modafinil?

Modafinil is typically used by entrepreneurs, college students at University who have difficult majors, and bankers/high-pressure sales jobs. Modafinil is used by these individuals because, as a powerful (yet also safe and approved) stimulant-type Smart Drug, Modafinil can have prominent effects on the user such as increased energy, better mood and focus, and can significantly improve productivity levels. Modafinil does this by increasing a number of prominent neurotransmitters in the brain, including dopamine, serotonin and norepinephrine, as well as histamine (the primary wakefulness promoting nootropic in the brain and the major nootropic that Modafinil acts on.)

Modafinil for Narcolepsy, What is Modafinil to a Patient?

Modafinil is a Schedule IV FDA approved drug for Narcolepsy in the United States, and is sold under the brand names Modafinil, Modalert, Modvigil, Provigil (the most popular one), and under other analogues of the drug, such as Adrafinil, Olmifon, Armodafinil, Walkert and Alertec. Modafinil is used as commonly off-label for its effects as a cognitive enhancer as it is used as a wakefulness-promoting drug. A number of biohacking and nootropic/internet marketing celebrities have even gotten famous off of the drug, including Tim Ferris and Dave Asprey, notable entrepreneurs who have admitted to using Provigil on a very regular basis.

Modafinil for Studying

What is Modafinil useful for when studying? Since Modafinil acts on a variety of neurotransmitters that aid in the brain’s executive functioning (in-fact the exact cocktail of neurotransmitters Modafinil acts on is why it has been deemed the world’s first effective “Smart Drug” in a recent clinical trial) such as Dopamine and Norepinephrine, powerful neurotransmitters that aid in memory, mood, focus and most notably…wakefulness. While these can all be very beneficial when studying, Modafinil is mainly beneficial for its use in improving productivity, and in allowing the user to work at a far quicker pace and for much longer than they otherwise would be able to.

What is Modafinil and What does it Look like for Entrepreneurs?

Entrepreneurs are another major spectrum in which the drug Modafinil is taken off-label. Silicon Valley and in any local tech start-ups will most undoubtedly have at least someone on the team who either uses Modafinil, or who knows someone who does (this is especially true among the engineers, coders and writers, those whose careers require them to put out large volumes of work on a very regular basis.)

Modafinil Benefits on the Brain

Modafinil has a number of ways it affects the brain. Benefits the drug can have include

-Increased energy levels

-Better mental endurance

-Improved focus

-More productivity

-Improved memory

These come as a result of the neurotransmitters that Modafinil affects in the human brain.

Modafinil Reviews on Longecity

Longecity, the primary nootropics forum on the web, is crawling with scores of reviews about Modafinil, and include users saying “let me work all night,” “made working actually fun!” and “It was hands down the only nootropic I’ve ever tried that was effective.”

Checkout these links for more info on what users are saying about Modafinil!

http://www.longecity.org/forum/topic/42413-how-to-potentiate-modafinil/

https://www.reddit.com/r/modup/comments/5g1oyd/excellent_service/

Modafinil Reviews on Reddit

We have our own Subreddit (if that’s not social proof I don’t know what is) with loads of users that back us on our business. You can get more info about this here

https://www.reddit.com/r/modup/comments/5g1oyd/excellent_service/

Modafinil Reviews on our Forum

You can checkout our reviews on our forum right here: https://www.modup.net/forum/

You’ll get a first-person review from the loads of loyal customers that loved our service and that continue to buy from us on a continuing basis.

Side Effects

With all its great perks, Modafinil does in-fact have some downsides, and so dosing should be attempted with caution. At doses of around 1-300mg per day, hardly any of these should occur (and when they do they will be fairly mild). Here is the rundown:

-Headache

-Dehydration

-Loss of Appetite

-Jitters (from the increase in stimulation)

-Insomnia

Typical Dosages

Typical dosages of Modafinil range from 1-400 milligrams per day. Always start out with the minimum effective dosage of 1-200 milligrams at a time (1/2 to one pill) in order to minimize side effects. Only increase to 3-400 milligrams once something resembling a tolerance to Modafinil has been built up. Modafinil has an extremely low risk of addiction, and should not have a withdrawal syndrome if taken on a regular basis.

Final Thoughts on the Uses of Modafinil

Modafinil is used for a wide variety of tasks, both off-label and on, and is used by vastly different backgrounds of individuals. What do you use Modafinil for (or thinking of using it for) comment down below and we’ll get back to you with how we can improve your first time on Modafinil!

Sources:

https://medlineplus.gov/druginfo/meds/a602016.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286657/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/

https://www.ncbi.nlm.nih.gov/pubmed/22051208

https://www.theguardian.com/science/2015/aug/20/narcolepsy-medication-modafinil-worlds-first-safe-smart-drug

30 Nov

Long-term Effects of Modafinil

Originally, chronic sufferers of sleep disorders would be the only long-term users of modafinil. Conditions such as narcolepsy can’t be cured, only managed. As with any medicine, long-term effects can appear far down the road. What are the long-term effects of Modafinil?

Studies have shown that modafinil is extremely safe for long-term use, with a 9-month study being the longest one available. As of yet there are no published safety studies that examine patients for a year or more.

Taking into account what we definitely know, we can also make some projections about modafinil’s long-term effects.

Long-term effects: What we know

The first question researchers ask is “Is this drug going to be effective in the long term?” This is a huge question to answer. If a patient develops tolerance or dependence on the medicine, it can have hazardous effects down the line.

Tolerance is when a drug no longer works as well as it did before, forcing you to take more and more. Tolerance and dependence go hand in hand; dependence means you suffer negative effects when you stop taking the drug, also known as withdrawal symptoms. A large study on patients with depression showed no potential for tolerance, dependence, or abuse.

No study has shown any negative effects on patients’ health, outside of the normal side effects.

Positive long-term effects

If there aren’t any negative long-term effects from modafinil use, could there be good ones? Aside from the obvious benefit of improving a person’s condition, there could actually be some very uplifting benefits of modafinil in the long term.

Productivity

Experts in psychology say it takes around 6 weeks to form a new habit. It’s possible to train yourself on modafinil to be more productive, and forge a habit that will stick with you even without the pill. Since modafinil helps you focus and get more done, you could have a long-term improvement in your work ethic if you use it diligently.

Organization

Life can get out of hand for all of us sometimes. Maybe you have too many things to do at once, or your work has many steps that create confusing situations. Whatever the case, you can become more organized by sticking to a modafinil schedule.

Make lists for the things you need to do, break down your activities into steps, and use modafinil’s ability to improve your executive cognition. Once you know how your brain works on modafinil, you could consciously do the same thing later.

Potential long-term problems

On the other hand, we could project some possible problems with modafinil when used for a long period of time.

Overloading

You might feel like you can take on the world and do anything with modafinil, but be careful not to devote your entire life to work. If you take on more than you can handle, your stress levels can rise. Stress is detrimental to your health, it can even shave years off of your life.

The key, as with everything, is balance. You absolutely can improve yourself and your behavior with modafinil, but be mindful of your work-life balance. Take a day off from time to time and relax. You’ve earned it with all that work you’ve done!

23 Nov

Modafinil Helps Patients with Brain Tumors

Modafinil continues to find novel applications in medicine. New research is being conducted based on a 2012 study that found modafinil useful for helping patients with brain tumors. Doctors diagnose over 70,000 brain tumors every year. Roughly 1/3 of them are malignant. In either case, brain tumors present unique complications for patients.

How modafinil helps patients with brain tumors

Modafinil itself won’t remove a tumor. You need serious chemotherapy or radiation treatments to do that. But there are two ways that modafinil can contribute to a patient’s recovery and quality of life.

Reducing the side effects of tumor treatment

First, modafinil helps to alleviate some of the symptoms of tumor treatment. Chemotherapy patients, for instance, experience extreme fatigue and exhaustion, which can make even basic tasks a chore. The extra energy that modafinil grants can offset the negative side effects of treatment. The result is that the patient is usually able to take on more treatments, helping them get better sooner.

Softening the Symptoms of Brain Tumors

The second, and the most interesting benefit of modafinil in tumor patients, is cognitive. Modafinil’s cognitive effects are the main reason the drug sells so well. Brain tumors can directly impact a person’s cognitive abilities, as does the treatment.

Many brain tumor patients find it difficult to think clearly, or suffer unusual mood swings. Memory also degrades in many cases. The brain is very sensitive and doctors still don’t fully understand how it works. But it’s pretty clear that a foreign object in the brain is not good. Tumors, depending on where they are, can disrupt normal brain functions. Imagine how frustrating it would be to feel your power to think slip away. Doctors are constantly searching for a way to help patients stay mentally strong while undergoing treatment.

With that in mind, this study compared modafinil to Ritalin and found that both were about equally effective in improving cognitive function, but modafinil produced fewer side effects. The patients who had deteriorated the most also benefited the most. While it was a small study, the researchers believe that the results would hold up in a wider investigation.

What you should do

Of course, if you or someone you know is dealing with a brain tumor, you never start any treatment without consulting a doctor first. In delicate situations like these people often feel helpless and desperate, willing to try anything. But going rogue can lead to more problems, especially if drugs interact in the wrong way.

We’re still a long way from curing cancer, but at least with modafinil patients can improve their recovery process and increase their quality of life.

 

 

21 Nov

Is Modafinil Addictive?

With modafinil use on the rise in students around the world, researchers are stopping to ask an important question: Is modafinil addictive, and if so, should we be concerned?

Modafinil enthusiasts highlight several case studies that show that modafinil is not addictive, but some outlying examples have shaken that theory up. In addition, the studies that are out there have not looked at the whole spectrum of addiction, which means modafinil could be more addictive than we previously thought.

The different kinds of addictive

Broadly speaking you can classify addictions into two distinct categories. First, you have physical dependency. This is when your body literally craves the drug. Uncomfortable withdrawal symptoms appear with physically addictive substances. Nicotine and Caffeine are two of the most common physically addictive chemicals we consume on a daily basis. Think about that headache you get if you miss your morning coffee, or how you can become irritable and jittery without your cigarette.

But that’s not the only type of addiction out there. Substances can also be psychologically, or mentally addictive. This occurs when you simply want more of the drug because you like its effects, but don’t necessarily feel a physical need to take it. Cocaine, surprisingly, is not very addictive physically, but psychologically it can be very powerful. With mental addictions, users often dose in a specific set of circumstances.

The repeated use of a drug in a certain circumstance forms a habit that can be difficult to break.

Modafinil: Not physically addictive

Numerous studies have shown that modafinil has little to no potential for dependency. One rare case was found by Indian doctors, but the patient in that case had a psychotic breakdown years prior due to his father’s death. He reportedly took larger doses of modafinil than normal, which led to him developing dependence. Outside of this severe case, no study has shown a solid link between modafinil and physical addiction.

Modafinil can be psychologically addictive

Teenrehabcenter.org recently added a section about modafinil abuse in young adults. The problem appears to be growing as more teens compete to get high marks on exams and enter the best universities.

For some students, modafinil can be a game changer. Imagine taking a pill and suddenly seeing your performance improve. That rush of positive feelings can push you to take more. Before you know it, you can’t study or take a test without modafinil. This dangerous cycle is what modafinil’s psychological addiction looks like. Parents are concerned.

Preventing modafinil addiction

The key to avoiding psychological dependence is to use modafinil, or any drug, sparingly and in moderate amounts. Save it for emergencies. Don’t make it an every-day habit even though you might benefit from it in the short term. It’s important to be able to be you without a pill.

When you do take modafinil, keep it to the 200mg standard dose. The shreds of evidence that support modafinil being addictive always involve higher doses.

Modafinil is extremely well tolerated and, in general, people have nothing to worry about. But if used improperly there is a slight potential for abuse. Stick to the guidelines here and you should have no trouble with modafinil.

 

14 Nov

Microdosing with Modafinil

Do Microdosing and Modafinil Mix?

A new trend in nootropic use has emerged in recent years with the concept of microdosing. Microdosing is when a user takes a dose that’s much lower than the typically recommended one. Is taking less really a better option?

Benefits of Microdosing

Those who embrace microdosing say that it gives you at least some of the benefits of a particular medicine or chemical without as much of the harmful risk. For instance, a dose that’s 25% of a regular dose may not show side effects while giving the user some benefits. People who are more sensitive to drugs can benefit from this approach.

Microdosers also suggest that using a lower dose allows you take more substances at once. This is especially popular in the nootropic world as people create “stacks” of compounds that they take simultaneously. In essence, it’s the “little bit of everything” method to improving your performance.

Nootropics can get expensive, so microdosing also helps to stretch your supply farther and save money. But does it actually work?

Micro dose, mega proof

Surprisingly microdosing is nothing new. While its recent popularity might make you think it’s a new development, the concept is as old as the pharmaceutical industry. Experiments throughout the 50s and 60s tried to use psychedelic drugs in micro doses to see if they had any therapeutic benefits for patients. LSD particularly was used in this regard and the results were quite promising before being shut down due to LSD’s addition to Schedule 1.

A bizarre reverse case of microdosing was with the Russian-made AMT, now illegal. It was originally designed to be a potent anti-depressant, and trials showed that with just a very small amount it was extremely effective. However people who took more than that amount started to have LSD-like symptoms including hallucinations, and production was halted.

What confounds doctors today is the potential for problems with the placebo effect. At small doses, it can be hard to tell if the patient is really experiencing effects from the drugs, or if it’s all in his mind. This makes microdosing something of a pseudo-science, because it’s so hard to measure.

Microdosing modafinil

A lot of people (myself included) like to chop a modafinil pill in half and take 100mg instead of 200. Others go even further and take 50mg at a time. Users have described this as a shorter effect, which can be useful for a late-afternoon dose when you still want to sleep at a reasonable hour.

Others who have tried 50mg find that the effect is too weak compared to what they are used to and would rather take more.

If you want to add modafinil to your microdosing stack, it might make sense to try 50mg and go up from there if need be. Doses smaller than that seem to be impossible to differentiate between real effects and placebo. As modafinil is well tolerated by most people, microdosing it seems to be somewhat pointless. Unless you have serious side effects from using modafinil, stick to the regular doses.

10 Nov

The Top 5 Things to Do on Modafinil

Modafinil is popular among a wide variety of people because of its ability to make normally boring tasks easy to handle. With that in mind, let’s look at…

The top 5 things to do while you’re on Modafinil.

Study

Of course this is first on the list! Students are by far the largest group of modafinil users. In many universities significant percentages of students report having used modafinil recently for studying. In some places this is over 25% of the student body, an astounding number when you consider that in the case of large campuses this represents over 25,000 people.

Why is Modafinil so good for studying? It helps you focus and concentrate on something for a long period of time, which makes it perfect for reading through those thick textbooks and dense PDFs. As an added bonus, it helps you to stay awake, which is great if you have to pull an all-nighter to get ready for that exam.

While there’s currently no real evidence that Modafinil improves memory and learning, you can expect to at least learn at your normal pace while getting more done.

Test-Taking

Naturally if Modafinil is good for those long study sessions, it should help you crunch the questions on your upcoming exam, right? Today’s exams are getting longer, and standardized testing in high schools and increasingly in universities demands more time and energy from students than they naturally have. Consider that some exams can last upwards of 3 hours. How do you maintain your focus on a grueling paper without some help? Modafinil can sharpen your brain when the test hits the table.

Writing

I write on Modafinil, and why wouldn’t I? It helps me to sit down and pound out the work, something notoriously difficult for a chronic procrastinator like myself. Writing can become tedious after a while, making it difficult to put together a long quality writing session. With Modafinil guiding you, you can settle into your favorite chair and type until your fingers bleed.

Obviously this is a huge advantage for anyone working on term papers or their thesis. Research papers benefit as well. I find that with my university work I’m able to dive deeper into the discussion and get absorbed into the research, producing quality references and a better paper overall.

Careful if you need to write something creative. Modafinil has been shown to limit divergent thinking, the key to coming up with clever solutions to problems.

Paperwork

Work in an office? Most people do nowadays. Nothing sucks the joy out of life like a stack of paperwork. It seems that no job can steer clear of the mountains of forms and documents needed by today’s companies and governments. Take it from a teacher, Marie, who gave us her story and highlighted how much Modafinil had helped.

At the end of the semester I have to make reports for EVERY student I taught. In a packed urban public school system that means writing around 150 separate documents. The worst part is how useless these are. Nobody really reads them, yet they’re required by the school board. A couple of years ago I discovered Modafinil and now it’s my secret weapon when the paperwork piles up. I actually got all 147 of my students’ files finished in a single day this year. I’m so proud! Couldn’t have done it without the teacher’s little helper though.

Burn through that boring paperwork in record time with Modafinil.

Cleaning

Another thankless, dreary task that simply must be done. Modafinil’s gift of making even the most mind-numbing activities bearable comes in handy here. I tend to do a single chore at a time and take a needless break between each one, which only drags out the process. With Modafinil however, I power through the whole workload in a single rush that leaves my flat dazzling in just a couple of hours.

Best part? You’ll be more thorough. Just like how Modafinil will lead you down the research rabbit hole, you’ll find your cleaning to be much more detailed and meticulous. You’ll never see me lift up the microwave and clean under there unless a round white pill made its way into my system that morning.

What else does Modafinil help you with? Share your stories and comments with us. We love hearing from you!

 

 

 

05 Nov

What is the Best Dosage of Armodafinil?

5

Armodafinil Dosages, What amount is Best?

 What is this?

Armodafinil otherwise referred to as Nuvigil is a special nootropic drug that when consumed by users helps to promote their wakefulness levels and concentration levels as well The drug is mainly produced by a pharmaceutical company known as Cephalon, and the drug was also approved for Public us by the FDA in mid-2007. While modafinil and armodafinil can be said to possess similar half-lives, the latter tends to reach a more Armodafinil Prescriptionpotent concentration level in the blood much later after consumption than modafinil. For this reason, armodafinil is a more potent wakefulness-promoting agent especially in users who have excessive daytime sleep complications or sleep apnea.

Benefits

Armodafinil is a legal drug that has approval from the FDA for treating a broad spectrum of sleep-related complications such as sleep apnea and daytime-related sleepiness. Besides that, the supplement also makes for an excellent solution for treating shift work disorder and chronic fatigue syndrome in some users. It is also a prevalent solution for students and medical practitioners who want immense focus levels.

Dosage

For complications such as narcolepsy, sleep apnea and shift work related sleep disorders, the recommended dosage for the drug ranges in between 150 mg and 250mg dosages especially in the morning. To be specific, for those who want t to improve productivity levels at work or perhaps when preparing for a test, the recommended dosage is 150mg.

Prices

Since the consumer market is packed with a broad spectrum of armodafinil versions but all with a similar potency level, the average price range tends to vary depending on various factors. For instance, the average price range that you are likely to come across when purchasing this supplement for your unique needs ranges in between 44$ to an average of 79$.

Safety Concerns

When it comes to all types of supplements, various health concerns are always available for any prospective user of the given drug. Since armodafinil is a highly potent drug, the recommended dosage is 150 mg and a maximum of 500mg in one single day. Surpassing the levels mentioned above would lead to liver toxicity and even harm your C.N.S system/

Long-term Use

Similar to using most types of nootropics that are available on the consumer market today, Armodafinil has some notable side effects that the users should take into account for their unique health needs. For instance, some of the long-term health concerns include anxiety, anorexia, nervousness and fatigue in some rare cases as well.

Research

According to a recent study by University Students in Harvard, students that used nootropics just before a test reported better grades and had enhanced cognitive capabilities as well. Besides that, the research study also documented that the users had experienced improved levels of both long and short-term memory as well.

Reviews on Longecity and Reddit

Tom Hopkins on Longecity says:

I have been using nootropic drugs for a long time now and without noticing any significant benefits of using the drugs. However since I tried out the armodafinil, I must say that my productivity results when it comes to completing my accounting task have skyrocketed. The additional benefit of using this drug is that it is legal and has no major side effects.

Lucy Deerson son Reddit says:

When it comes to mind altering substances or prescriptions, I often recommend that my medical clients stay away from the drugs as far as possible. However, since we discovered Armodafinil, I must say that I have recommended this drug to a broad spectrum of clients including those who have demanding dissertations to write, academic papers and even those who have to drive for long distances. What’s more is that it is readily available online.

Side Effects

Armodafinil is a potent nootropic drug that should be consumed with some level of caution. Since it increases focus and reduces the effects of sleep, it’s important that you consume it several hours before retiring to bed. Besides that, overdosing on the drug may lead to liver toxicity, and it may harm your cognitive capabilities.

Final Thoughts

Broadly speaking, this supplement is a worthwhile investment for anyone who wants to improve their overall focus and concentration levels. The drug works well to mitigate a broad spectrum of health complications, and users are therefore recommended to use it as recommended on the packaging or perhaps by the doctor.

 

04 Oct

Provigil Supplement Facts

Provigil Supplement Facts

What is Provigil?

Modafinil is an attentiveness advancing specialist utilized for treatment of disarranges, for example, narcolepsy, shift work rest issue, and over the top daytime sluggishness connected with obstructive rest apnea. It has additionally seen across the board off-name use as an indicated insight improving specialist. In English-talking nations it is sold under the brand names Alertec, Modavigil, and Provigil. In the United States modafinil is named a timetable IV controlled substance and confined in accessibility and utilization, because of worries about conceivable compulsion potential. In most different nations it is a physician endorsed medicate however not generally legitimately limited. It is commonly compared to many other nootropic stimulants, such as Aniracetam or Phenylpiracetam.

 

What benefits come from Provigil? 

Provigil is a nootropic that builds readiness and vitality levels – particularly in individuals who don’t get enough rest. It is every now and again utilized as a segment as a part of nootropic stacks intended for contemplating and profitability.

Provigil surveys regularly express that this supplement gives them a much cleaner jolt of energy than caffeine and different stimulants. Consequently, it has gotten to be famous for off-mark use as a fixation enhancer.

Clinically, it is recommended to individuals who experience the ill effects of narcolepsy, obstructive rest apnea and other rest related clutters. There is, nonetheless, a vast online drug store market from which numerous clients can buy Modafinil without a remedy universally.

 

Dosages regarding Provigil

The prescribed measurements of PROVIGIL for patients with narcolepsy or OSA is 200 mg taken orally once per day as a solitary dosage in the morning.

 

Dosages up to 400 mg/day, given as a solitary measurements, have been all around Modafinil Supplement Factsendured, however there is no steady confirmation that this measurement presents extra advantage past that of the 200 mg/day dosage.

 

The prescribed measurements of PROVIGIL for patients with SWD is 200 mg taken orally once per day as a solitary dosage roughly 1 hour preceding the begin of their work shift.

 

Measurement Modifications In Patients With Severe Hepatic Impairment

 

In patients with extreme hepatic debilitation, the measurement of PROVIGIL should be decreased to one-portion of that suggested for patients with ordinary hepatic capacity.

 

Side effects from Provigil

Basic symptoms of Provigil include: cerebral pain and sickness. Opposite reactions include: anorexia and xerostomia. See beneath for a far reaching rundown of unfriendly impacts. Significant Side Effects

On the off chance that any of the accompanying symptoms happen while taking modafinil, can include

  • Dark, falter stools
  • obscured vision or other vision changes
  • mid-section torment
  • chills or fever
  • awkwardness or flimsiness
  • perplexity
  • unsteadiness or swooning
  • expanded thirst
  • mental wretchedness
  • issues with memory
  • quickly changing mind-sets
  • shortness of breath
  • sore throat
  • trembling or shaking
  • inconvenience in urinating
  • uncontrolled developments of the face, mouth, or tongue
  • strange draining or wounding
  • unusual tiredness or shortcoming

 

Research

Modafinil is a pharmaceutical intended for use in rest related disarranges, and is identified with enhanced mental capacity in a restless state. The expression “modafinil” alludes to a racemic blend of two isomers, R-modafinil and S-modafinil. The R-isomer without anyone else is alluded to as armodafinil. An investigation of studies has noted, notwithstanding, that armodafinil has a 18% higher Cmax esteem with a more quick Tmax and that the general AUC of armodafinil gives off an impression of being 32-40% more prominent than modafinil. Modafinil is by all accounts ready to increment extracellular levels of dopamine in the rodent nucelar accumbens and prefrontal cortex and the pooch caudate core. It has been appeared to involve both the dopamine and noradrenaline receptors (in the striatum) and avoidance of dopamine receptor inhabitance nullifies the rest advancing impacts in mice, proposing this component of activity is vital to the rest advancing impacts.

 

Long term usage effects

Nobody truly knows without a doubt because of the freshness of this substance and the comparing absence of long haul concentrates on.

Certain unfriendly impacts are generally reported among long haul clients, the greater part of which emerge from the main driver of lack of sleep. Modafinil makes it not entirely obvious the body’s characteristic interest for rest. After some time this can prompt a considerable overdraft in a client’s “rest bank.” Sleep is the point at which a great deal of the body’s repair work, both physical and mental, is led. In this way, weariness and quickened maturing are conceivable results. A state of mental reliance on modafinil is additionally liable to create, keeping in mind the end goal to keep up the “taking on too much work” way of life.

Another ordinarily reported negative impact is harm to the mouth locale, again coming about because of disturbance to the ordinary resting cycle. This come about because of having a drier mouth than regular as the body delivers less spit while alert than while sleeping – consider how frequently you’ve seen somebody dribbling while snoozing. This dry mouth condition can prompt bruises and ulcers in the mouth and maybe harm to the teeth.

Unless you have a dozing issue, for example, narcolepsy or movement work rest issue, it is positively to your greatest advantage to direct your utilization of modafinil. Research a decent staging regimen and just take it when totally important.

 

Narcolepsy

Provigil was initially affirmed by the FDA as a treatment for narcolepsy. It was hailed in light of the fact that it was a contrasting option to stimulants, which were the main other treatment for narcolepsy at the time, yet had a ton of reactions, were anything but difficult to develop resilience to, and could be manhandled.

 

Conclusion

Provigil is a drug that can be used to help treat many things. You will see an increase in your alertness and potentially be able to be more alert and awake and be able to focus where you weren’t able to before.

 

28 Sep

Can Modafinil Treat Methamphetamine Addiction?

One of modafinil’s most surprising potential uses is in its ability to treat addictions. Studies have strongly supported modafinil as an aid to recovering addicts, particularly for cocaine use. But what does the data say about methamphetamine?

The global meth problem

Meth might not be the first drug you think of when addiction comes to mind, yet in many countries it’s extremely prevalent. Around 18 million Americans have tried meth recently, and as many as some 12 million are regular users.

Meth is very popular in Europe, particularly in Scandinavia. In Thailand, for instance, meth is so widespread that it can be found in common markets right next to vegetables and chicken, despite its illegality. In Australia where it is very difficult to get drugs, meth can go for over $300 per gram.

Recent Thai news reported that the government is contemplating decriminalizing the drug since users are afraid to seek help due to the strict drug laws currently in place. They also believe that using modafinil can help these addicts.

The multiple-Emmy-winning series Breaking Bad revolved around meth. Clearly meth is a global issue that has made its way into our pop culture.

Modafinil as a treatment for Meth abuse

Currently there is not much information on modafinil for meth addiction. The most recent study with positive results came in 2010 and was carried out on rats. The idea was to get rats addicted and then see if modafinil could reduce their regular use. The study was successful, although not enough to get the rats to stop taking meth altogether.

When it comes to actual human trials, the evidence is slimmer and less encouraging. The largest study comes from 2011 where 210 participants were placed into three equal groups of Placebo, Modafinil 200mg, and Modafinil 400mg. Over 12 weeks of monitoring the study found that neither group outperformed the others.

What they did find was that patients were not regularly taking their modafinil which may have been the problem. When they looked at all 210 participants, those who consistently tested positive for modafinil were likely to have longer runs of abstinence. So perhaps modafinil helped out.

Another 2009 study, this one on just 71 people, came up empty handed and found no evidence to support modafinil use.

Why modafinil might work

Critics of these studies point out that modafinil has potential that simply hasn’t been realized yet. Since modafinil is very safe and well tolerated, and non-addictive, it could be very helpful. On top of that, it improves cognition and mood, two areas that are dramatically affected by meth withdrawal.

Will we see Modafinil Clinics in the future? Probably not, at least not without greater funding into these studies.

09 Sep

Is Modafinil Safe to Take During Pregnancy

Don’t Take Modafinil during Pregnancy

Recently this blog tackled several important questions about reproductive health: Premature Ejaculation and Women’s hormonal birth control. We add to that series today with an investigation into modafinil’s effects on pregnant women. Based on the FDA’s classification of modafinil, this blog and most medical professionals would recommend you do NOT take modafinil during pregnancy.

How the FDA classifies medicines for pregnancy

The US FDA is the best source for a drug’s safety during pregnancy since part of the approvals process for any medication is to provide at least some basic evaluation of the effects on fetuses and breastmilk. Based on these results, the FDA categorizes all medicines into 5 groups: A, B, C, D, and X. It works like this:

  • Category A: Proven completely safe
  • Category B: No evidence to suggest any risk, but not proven safe
  • Category C: Animal studies show adverse effects, but no human trial evidence
  • Category D: Evidence of adverse effects on human fetuses
  • Category X: Proven to produce extremely negative effects.

In all of these categories the common thread is how much evidence exists to support the data. Category B, for instance, could be just as safe as A, but in order to move into the A group studies must consistently demonstrate no negative impact whatsoever. Likewise, harm to animals is good enough for category C, but D requires evidence of effects on humans.

Why does the scale jump from D to the rather terrifying X rating? It all comes down to safety.

In categories C and D, there is evidence of negative effects, but the benefits of the medicine may outweigh those negative effects on the fetus. For instance, many anti-anxiety medications are found in categories C and D. A doctor might argue that it’s better for the mother to take these pills and risk some minor harm to the baby, rather than not take them and perhaps suffer an anxiety attack that leads to a miscarriage.

But Category X is reserved for substances that will always harm the fetus more than it helps the mother, for instance many of the cholesterol-lowering drugs are in this group. A little extra cholesterol probably won’t kill a young mother, but would absolutely kill the baby.

Modafinil’s FDA classification for pregnancy

Modafinil is category C, meaning that no proof of human damage exists, but there is reason to be concerned. It’s recommended that women do not take modafinil while they are pregnant. Considering the risk-reward calculation, it’s almost impossible to imagine a scenario where modafinil was absolutely necessary. While you might want to have some extra energy to help you carry that baby around inside of you, don’t take modafinil if you’re pregnant.

What about breastfeeding?

Modafinil is also excreted through breastmilk, and while there are currently no studies that show what happens to babies who are exposed to modafinil, doctors agree that it’s best to avoid taking modafinil while you breastfeed.

Modafinil has a potent effect on the brain, and in a brain that is still forming and developing, it’s unclear if this effect could have a negative impact down the line. Modafinil has been approved for young children, but not babies. People want babies to sleep, not stay awake. So given the lack of a practical application, there is no research.

So listen up pregnant women, stay away from modafinil!