28 Sep

Can Modafinil Treat Methamphetamine Addiction?

One of modafinil’s most surprising potential uses is in its ability to treat addictions. Studies have strongly supported modafinil as an aid to recovering addicts, particularly for cocaine use. But what does the data say about methamphetamine?

The global meth problem

Meth might not be the first drug you think of when addiction comes to mind, yet in many countries it’s extremely prevalent. Around 18 million Americans have tried meth recently, and as many as some 12 million are regular users.

Meth is very popular in Europe, particularly in Scandinavia. In Thailand, for instance, meth is so widespread that it can be found in common markets right next to vegetables and chicken, despite its illegality. In Australia where it is very difficult to get drugs, meth can go for over $300 per gram.

Recent Thai news reported that the government is contemplating decriminalizing the drug since users are afraid to seek help due to the strict drug laws currently in place. They also believe that using modafinil can help these addicts.

The multiple-Emmy-winning series Breaking Bad revolved around meth. Clearly meth is a global issue that has made its way into our pop culture.

Modafinil as a treatment for Meth abuse

Currently there is not much information on modafinil for meth addiction. The most recent study with positive results came in 2010 and was carried out on rats. The idea was to get rats addicted and then see if modafinil could reduce their regular use. The study was successful, although not enough to get the rats to stop taking meth altogether.

When it comes to actual human trials, the evidence is slimmer and less encouraging. The largest study comes from 2011 where 210 participants were placed into three equal groups of Placebo, Modafinil 200mg, and Modafinil 400mg. Over 12 weeks of monitoring the study found that neither group outperformed the others.

What they did find was that patients were not regularly taking their modafinil which may have been the problem. When they looked at all 210 participants, those who consistently tested positive for modafinil were likely to have longer runs of abstinence. So perhaps modafinil helped out.

Another 2009 study, this one on just 71 people, came up empty handed and found no evidence to support modafinil use.

Why modafinil might work

Critics of these studies point out that modafinil has potential that simply hasn’t been realized yet. Since modafinil is very safe and well tolerated, and non-addictive, it could be very helpful. On top of that, it improves cognition and mood, two areas that are dramatically affected by meth withdrawal.

Will we see Modafinil Clinics in the future? Probably not, at least not without greater funding into these studies.

09 Sep

Is Modafinil Safe to Take During Pregnancy

Don’t Take Modafinil during Pregnancy

Recently this blog tackled several important questions about reproductive health: Premature Ejaculation and Women’s hormonal birth control. We add to that series today with an investigation into modafinil’s effects on pregnant women. Based on the FDA’s classification of modafinil, this blog and most medical professionals would recommend you do NOT take modafinil during pregnancy.

How the FDA classifies medicines for pregnancy

The US FDA is the best source for a drug’s safety during pregnancy since part of the approvals process for any medication is to provide at least some basic evaluation of the effects on fetuses and breastmilk. Based on these results, the FDA categorizes all medicines into 5 groups: A, B, C, D, and X. It works like this:

  • Category A: Proven completely safe
  • Category B: No evidence to suggest any risk, but not proven safe
  • Category C: Animal studies show adverse effects, but no human trial evidence
  • Category D: Evidence of adverse effects on human fetuses
  • Category X: Proven to produce extremely negative effects.

In all of these categories the common thread is how much evidence exists to support the data. Category B, for instance, could be just as safe as A, but in order to move into the A group studies must consistently demonstrate no negative impact whatsoever. Likewise, harm to animals is good enough for category C, but D requires evidence of effects on humans.

Why does the scale jump from D to the rather terrifying X rating? It all comes down to safety.

In categories C and D, there is evidence of negative effects, but the benefits of the medicine may outweigh those negative effects on the fetus. For instance, many anti-anxiety medications are found in categories C and D. A doctor might argue that it’s better for the mother to take these pills and risk some minor harm to the baby, rather than not take them and perhaps suffer an anxiety attack that leads to a miscarriage.

But Category X is reserved for substances that will always harm the fetus more than it helps the mother, for instance many of the cholesterol-lowering drugs are in this group. A little extra cholesterol probably won’t kill a young mother, but would absolutely kill the baby.

Modafinil’s FDA classification for pregnancy

Modafinil is category C, meaning that no proof of human damage exists, but there is reason to be concerned. It’s recommended that women do not take modafinil while they are pregnant. Considering the risk-reward calculation, it’s almost impossible to imagine a scenario where modafinil was absolutely necessary. While you might want to have some extra energy to help you carry that baby around inside of you, don’t take modafinil if you’re pregnant.

What about breastfeeding?

Modafinil is also excreted through breastmilk, and while there are currently no studies that show what happens to babies who are exposed to modafinil, doctors agree that it’s best to avoid taking modafinil while you breastfeed.

Modafinil has a potent effect on the brain, and in a brain that is still forming and developing, it’s unclear if this effect could have a negative impact down the line. Modafinil has been approved for young children, but not babies. People want babies to sleep, not stay awake. So given the lack of a practical application, there is no research.

So listen up pregnant women, stay away from modafinil!

04 Sep

Armodafinil Prescription Benefits

Armodafinil Prescription

Armodafinil Prescription Benefits

What is Armodafinil? : Armodafinil is a popular oral drug which is used in order to improve wakefulness. It works pretty similar like Provigil. This medication efficiently promotes wakefulness by stimulating the human brains. Armodafinil is often prescribed for promoting wakefulness associated with several chronic sleep disorders like obstructive sleep apnea or hypopnea syndrome, narcolepsy, & shift work sleep disorder etc. Additionally, this drug is safe to consume and it’s FDA approved.

 

 

Benefits Of Armodafinil : When it was originally developed, this pharmaceutical was primarily intended to treat the individuals who suffer from an overwhelming daytime fatigue. Again using this drug as a wakefulness enhancer, its users can effectively treat the instances of narcolepsy, insomnia, sleep apnea, and various other effects that are often experienced during shift work. Plus, it acts as a cognitive enhancer and helps its users to greatly improve focus & concentration.

 

 

 

Dosage : Armodafinil is purer & more refined compared to the other smart drugs available in its category. It’s sold on account of a valid prescription in 50, 150, & 250 mg tablets. The standard recommendations of this drug vary based on the symptoms that a patient is currently having. For those who’re suffering from narcolepsy & sleep apnea, generally, 150 – 250 mg dosage is taken daily. Shift-workers are majorly prescribed to take a 150 mg dose an hour before their respective shift.

 

 

 

Long-term Use Of Armodafinil : The long-term usage of Armodafinil can be beneficial for a patient based on his/her medical condition. However, the actual long-term uses & associated benefits of this drug is undiscovered till now. Whether you’re having this drug for a long time, never exceed its daily dosage limit as prescribed by your physician.

 

 

 

Short-term Use Of Armodafinil : Unlike its long-term usage, the short-term usage and associated benefits of Armodafinil are well-established and well-known to the world. A noticeable increase in overall energy and stamina can be easily observed after using Armodafinil. Plus, the users experience to be more mindful, observant, and thoroughly focused on using this drug. With a continued usage of this drug, the problems of excessive sleepiness can be also treated.

 

 

Use For Narcolepsy : Narcolepsy is a chronic neurological disorder which affects the control of sleep & wakefulness. Armodafinil is widely used in order to treat the problems of excessive sleepiness caused by narcolepsy. That’s why this drug is considered to be listed in a class of medications that are collectively named as “wakefulness-promoting agents.”

 

 

 

Nootropic Use : Additionally, Armodafinil has its potential benefits while it is used as a nootropic. Even, it is a classified as a Nootropic smart drug that is used in order to increase alertness & wakefulness, resulting in an overall enhanced & improved mental performance. Furthermore, this drug is also commonly used for several off-label purposes blastas a powerful and effective cognitive enhancer by the eminent nootropic community.

 

 

 

Reviews : Armodafinil has been approved by the FDA in the entire USA since 2007. Even, it is globally popular in several other territories too. According to a recent publication, it has been found that around estimated 1.6 million users have already purchased Armodafinil during the last three years. Most of them have found this drug utterly helpful and highly effective too.

 

 

 

Side Effects Of Armodafinil : Armodafinil doesn’t have any major side effects. Although, a very few minor side effects have been reported by some of its users such as a headache, dizziness, constipation, diarrhea, loss of appetite, and dry mouth etc. These side effects can vary from person to person. In case you’re facing severe health issues apart from the above-mentioned symptoms, you should definitely consult with your physician at the earliest.

 

 

 

Research : Several enthusiastic groups of researchers and scientists have collectively conducted multiple kinds of research on this smart drug, Armodafinil. Based on their scientific study, it has been proved that this drug is highly efficient as a wakefulness promoting agent and cognitive enhancer. That’s why this drug has been globally accepted by its users and various experienced physicians. Currently, they are also conducting several types of research in order to explore its future possible uses.

 

 

 

Conclusion : Armodafinil, being a brain-enhancing drug is widely used for treating inattentiveness, mental fatigue, a lack of focus, and excessive sleepiness. Even, this eugeroic stimulant is well capable of producing the long-lasting mental arousal & alertness without causing irritation, agitation, or any other unpleasant side effects. Overall, it’s a powerful & effective smart drug.

02 Sep

Modafinil’s Potential for Abuse

Modafinil’s low potential for abuse proven by studies

One of the reasons modafinil has been praised as an effective treatment for so many conditions is that it has a very low potential for abuse. But just what does that mean? What constitutes abuse? And what is a low potential? To answer these questions we need to analyze what scientists and researchers examine as criteria for abuse, and explore modafinil’s effects in controlled studies.

How abuse is defined

Drug abuse is effectively the use of any drug with negative consequencces beyond the expected side-effects of the drug itself. So it’s not abuse to take your chemotherapy medicine just because it has some negative consequences, nor is it a problem to take some illegal drugs provided they don’t cause you significant problems.

But what researchers have to consider is the potential for abuse. This is determined by a number of factors, and a full guideline by the FDA outlines some of the most important variables.

Laboratory tests will give rats an option to eat a regular food pellet or press a lever for a pellet that contains the drug being tested. If the rat consistently selects the drug, then it’s clear that it has a higher potential for abuse.

Tests are also done to figure out what effect the drug has on the brain. Dopamine is particularly a concern. Dopamine is the neurotransmitter that tells your brain to do something again by giving it a pleasurable feeling. A high dopamine response is characteristic of cocaine for example.

Modafinil’s potential for drug abuse

Modafinil has been shown to increase dopamine uptake, causing mild sensations of euphoria which some users report. In a similar study, it actually multiplied the effects of cocaine significantly.

Another study showed that it has a very low potential for abuse compared to common amphetamine drugs, which are often used for the same effects. Ritalin and Adderall fall into this category. Users did not feel the urge to re-dose, a very important indicator of safety, as that urge is connected to addiction.

Is off-label use abuse?

This question is one of the big ones pushing further research into modafinil’s potential for abuse. As many students and young workers take modafinil for off-label benefits, there is concern that they may develop a modafinil habit.

The key thing to consider is whether your modafinil use is affecting your life in a negative way. If you can’t function without it, then maybe it’s a problem. If you’re taking too much and losing sleep, which leads to taking more modafinil the next day to compensate, then you’re in a potentially dangerous loop.

Be conscious of how you use your medicine and avoid patterns of behavior that put you at risk. Modafinil itself is relatively harmless and unlikely to become a problem, but when misused it could lead to that exact situation.