24 May

Korean Study Reaffirms Modafinil’s Safety

As off-label use of modafinil becomes the rule rather than the exception researchers have scrambled to evaluate the safety of this behavior. Most early studies focused specifically on patients with the conditions that modafinil was designed to treat, such as narcolepsy. However, the last five years have produced several interesting studies and peer reviews that evaluate modafinil’s safety for off-label use. A 2012 Korean study reaffirms modafinil’s safety, and is of particular interest because it was conducted with a military focus.

Modafinil in the military

This topic has been touched on before so I’ll keep it brief. Modafinil is of extreme interest to the military who is always looking to give their soldiers an advantage. Combat fatigue is one of the greatest weaknesses of the human soldier. Modafinil can reduce that and thus extend a soldiers useful time. This is especially true in the air force where pilots may have to engage for hours on end without stopping until the fight is over. This Korean study was funded by the Agency for Defence Development, which is an R&D branch of the Korean military.

I’m not military, so why should I care?

Good question! The fact is that the military is comprised of regular everyday people like you and me. In fact, a military population by simple logic must consist of healthy individuals. You can’t have narcoleptics holding guns in a firefight. Effectively the military’s use of modafinil is exactly the same as anyone else’s off-label use. They want to stay awake and alert longer, and so do you.

The study evaluated off-label users and compared findings from other studies and arrived at an impressive conclusion.

The results are in

Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.

The first half should make total sense, right up until the world’s longest word pops up. Psychoneuroimmunological. If you needed a few tries to say that one out loud don’t feel bad, so did I. Basically there’s a small amount of evidence that suggests that modafinil could repress the immune system in some way, thus increasing the chances of infection. How serious this is up for debate, and that’s precisely why Dongsoo Kim (the author) recommends further studies in the area. Psychoneuroimmunological is a fancy way of saying that we need studies that examine the effects of modafinil on the immune system, the brain, and the mind, preferably all three to figure out exactly what (if any) impact the drug has on the immune system.

This research is also needed because of another point mentioned in the study: Stress. Stress has a proven impact on the immune system, so any further impact from a drug could greatly increase the rate of infection. While the stress of exams isn’t on the same level as the stress a soldier or a cancer patient might experience, stress is relative. For a student in secondary school or university, those final exams might be the worst thing they’ve ever experienced, meaning that they feel just as much stress as the fighter being shot at or the person undergoing chemotherapy.

But the key point of the study and one we should take home today is that modafinil can be used by anyone. There really isn’t any kind of healthy individual that can’t take modafinil. So if you’ve been considering it, give it a try.


04 Apr

Modafinil in the News

Modafinil in the News is a segment where we bring some of the latest developments in the modafinil world together here on Modafinil.co.uk

Modafinil, Schizophrenia, and Shenanigans

A study from 2008 in India reported that modafinil was a useful aid to patients taking atypical schizophrenia medications, specifically Olanzapine, Risperidone, and Clozapine. These medications are more affordable in underdeveloped countries and therefore are more commonly used to treat the prevalent mental disorder. Unfortunately they come along with two problematic side effects: Weight gain and daytime drowsiness. The researchers immediately thought of modafinil and put it to use.

And then they did so again in 2014, and once more in 2015. Or did they? Discover Magazine noted that the text between the 2015 and 2008 versions was 88% identical, and that one of the original authors works on the editorial board of the journal where the studies were published.

So, while the first test may have shown that modafinil helped these patients, it seems that any further tests could be nothing more than a fabrication. Hopefully some law-abiding westerners can take this brilliant idea and make it legit.

Smarter, safer, so says Scientific American

Safe, says the study

Scientific American has reported on a University of Oxford study which examined over 24 modafinil related investigations. What for? The Oxford researchers were looking to find solid evidence that modafinil helps with cognition. It’s been a hotly debated subject because every test has used a variety of different methods and that creates inconsistency. How do you test cognition, or brain power, anyway?

Well, the results came in loud and clear: The more complex the task in the study, the better the modafinil patients did compared to placebos. The simple tests showed no discernable improvement with modafinil, meaning that any difference they saw was still within the margin of error on the study.  Best part, they found no negative mental side effects from using the pills in any study, so they’re safe.

So what’s that mean for you? Get out there and put your pills to good use. Don’t waste them on the simple stuff, find something challenging that’ll really get the gears turning in that head of yours.

A New Formula for Narcolepsy

As patents expire, companies seek to find new ways to get their brand-name power back. One of those is by crafting up a new formula. The same modafinil when combined with another medicine in the same pill becomes an entirely new drug in the eyes of the patent office, and that means big profits for the pharmaceutical company. Theranexus is a new company pushing a new blend of their own medicine with modafinil to be even more effective for fighting narcolepsy.

Interestingly they’re backed by some pretty big people. CEA, one of the most important research institutes in France, is backing their project and pushing it forward.

When it comes to good modafinil research (and not that Indian funny business) the more the merrier, I say.


01 Jan

Can you Drink Alcohol on Modafinil?

Many medications recommend not drinking due to the possibility of a bad reaction between the two chemicals. This advice is often ignored by many people who find that it is usually a doctor’s over-cautious suggestion, and that little actual harm will come from doing so. However, every medicine is different and in some instances the warning should be taken very seriously.

The makers of modafinil discourage drinking while on modafinil. However there is no explicit warning that combining the two can be hazardous.

Given modafinil’s status as a popular drug for university students, and university students’ penchant for parties, it shouldn’t surprise anyone that there are quite a few reports of individuals mixing the two substances.

Dangers of drinking alcohol while on modafinil

While modafinil and alcohol do not interact in a negative way, one can amplify the other’s side effects.

For instance, both alcohol and modafinil dehydrate the body faster, meaning that if you do not drink more water (which most drinkers often forget to do) you’ll be in for a rough hangover the next day, as well as the potential risk of dehydration and overheating if you’re dancing or in a hot climate. This is very dangerous and care should be taken to stay hydrated every time you’re drinking, modafinil or no.

Another risk is that you can become drunker than you expected. One possible reason for this is that modafinil reduces appetite, and if you have not eaten before drinking you will feel the effects of alcohol faster. Secondly, modafinil combats the depressant effect of alcohol. You may not feel as sleepy or quite as drunk as you really are, leading you to drink more and assume that everything is fine. When the modafinil wears off, or if you continue drinking, you can suffer disastrous consequences. Users have reported drinking to the point of blacking out, a result of not being aware of how intoxicated they actually were.

Safely drinking alcohol on Modafinil

If you have taken modafinil and you are going to be drinking, you should exercise caution. Eat regularly as you normally do, even if you have a reduced appetite. Make sure to drink more water than you typically would, although this may mean a few extra trips to the bathroom. Above all, do not drink in excess. Respect your regular limits with alcohol, even though modafinil may enable you to surpass them for a moment, the consequences later can be serious.

When it comes to drinking and medication, safety should be your first priority. Avoid mixing modafinil and alcohol, and do not use modafinil as a means to stay up and party all night. If you’ve taken modafinil in the morning or early afternoon and are going out that night, be aware that it takes over 12 hours for modafinil to leave your body. Don’t forget about that dose you had earlier in the day. Be smart with your smart drug.